New Course on Biotechnology

Optimizing Production Processes in Biopharmaceutical Manufacturing

This new course gives you the opportunity to learn and use the systematic approach to process development that has been developed and used in the Chemical Process Industries (CPI) for over 50 years. Using these simple tools you will be able to look at your overall production process and determine were the critical areas are. With this information you will be able to pick the most cost effective production equipment, minimize and control raw materials and waste production, organize and control product flow through the process, and better design methods to improve reliability and regulatory compliance. In the end it will help you minimize the cost and time required to make the transition from the laboratory to the production plant.

An outline of the material to be covered in this course is given below. For more information on this and other biotechnology related courses contact University of Wisconsin-Madison, Department of Engineering Professional Development


OPTIMIZING PRODUCTION PROCESSES IN BIOTECHNOLOGY


Optimizing Biotech Processes

This new course gives you the opportunity to learn and use the systematic approach to process development that has been developed and used in the Chemical Process Industries (CPI)for over 50 years. Using these simple tools you will be able to look at your overall production process and determine were the critical areas are. With this information you will be able to pick the most cost effective production equipment, minimize and control raw materials and waste production, organize and control product flow through the process, and better design methods to improve reliability and regulatory compliance. In the end it will help you minimize the cost and time required to make the transition from the laboratory to the production plant.

What You Will Learn

During this three day course you will learn how to generate and use the two most basic tools created for any manufacturing facility, Process Flow Diagrams (PFDs) and Piping and Instrumentation Diagrams (P&IDs). You will learn how to take laboratory data and generate PFDs so that you can quantify the material, space, and personnel requirements needed to produce your product. This information will allow you to see which areas of your process are the most critical and determine which types of equipment (or unit operations) are best suited for your specific production needs. Since these documents encompass your entire production process you will be able to use them to quantitatively determine how changes in one area or piece of equipment will effect the operation of operations both before and after it. Information will be supplied on how to generate PFDs using generally available Computer Aided Drawing (CAD) programs linked to spreadsheets, or using specialty programs specifically designed to generate and optimize PFDs for the Biotech industry.

You will learn about de-bottlenecking your production process and learn the advantages of more closed and semi-continuous operations. Many pieces of equipment from the CPI will be investigated to show how these methods can be modified for Biotechnology in order for you to achieve more efficient production process. Numerous examples of these solutions will be given.

Detailed coverage of Piping and Instrumentation Diagrams (P&IDs) will be given, showing how these documents can be used to plan and control the operation of your process. We will also cover how these documents can be used to control the construction and capital cost of your facility. Whether you are embarking on the construction of a full scale production plant, or just retrofitting a lab to accommodate the needs of Phase I clinical trials, learning to generate and/or use P&IDs will result facility that best meets your requirements.

We will also cover how you can use these tools to help you satisfy the regulatory requirements of your facility.

Lastly, we will wrap up all of the subjects we have covered and show how you can use them practically to bring your products successfully out of the laboratory and into production.

Who Should Attend

Course Outline


Day one

Overview
Challenge of moving products from the laboratory to production Tools for looking at the Big Picture

Manufacturing Production Techniques Methods

Process Flow Diagrams (PFDs)

Day Two

Closed and Semi-continuous Equipment and Unit Operations

Piping and Instrumentation Diagrams (P&IDs)

Day Three

Procedures, Quality Control, and Regulatory Compliance

Putting it all Together

Challenges for the Future

Course Instructors

John Kossik, John has over 14 year experience in the Chemical Process Industries, in both supervisory and engineering positions in both plant design and operations. His design experience includes the process design of two mammalian cell culture facilities. He is also the author of numerous articles on the application of industrial techniques in Biotechnology. Outside of Biotechnology John has design and operations experience in many industries ranging from Pulp and Paper to refining, to fine chemical production. He is a member of AIChE and ISPE.


Send comments or questions to John Kossik at jmk@steadfastequipment.com
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Last Updated 8/8/02