Technical Articles and Columns I have Written:

Genetic Engineering News Column

Monthly column on process improvements in Genetic Engineering News. A list of the past columns on this subject are:

• "Transferring Unit Operations from Chemical Process Industries to Biotech"October 15, 1996
• "Semi-Continuous / Steady-State Reactor Equipment for Bioprocess Operations"November 15, 1996
• "On Using Supercritical Fluids for Bioprocessing Downstream Operations"December 15, 1996
• "Automated Buffer Prep Equipment"January 15, 1997
• "Biotech Cake Filtration Equipment"February 15, 1997
• "Solids Handling in Biotechnology"March 15, 1997
• "Pumps for use in Biotechnology"April 15, 1997
• "Bioprocessing Techniques from the CPI"May 15, 1997
• "Using Process Flow Diagrams in the Design of New Biotechnology Equipment" July 1997
• "Spray Dryers for Biotechnology" October 1997
• "Closing in Biotech Processes Early" November 1997
• "Piping and Instrumentation Diagrams to Control Biotech Projects Big and Small" December 1997
• "Protection Of Pressure Vessels From Overpressurization" February 15, 1998
• "Waste Treatment For Biotechnology" March 15, 1998
• "Using Heat Exchangers to Improve Bioprocess Operations" May 15, 1998
• "Lack of Innovation in Equipment Development" June 15, 1998
• "Analyzing the Production Process" August 1998
• "Scaling Up to Production Volumes" October 15, 1998
• "Scaled-down Equipment" January 1, 1999
• "Vacuum Drum Filters for Biotech"February 15, 1999
• "Disposable Unit Operations" April 15, 1999
• "Designing Biotech Facilities"May 15, 1999
• "What to do When You Don’t Need a Full Time Process Engineer"June 15, 1999
• "Liquid Flow Technology Operations"August 15, 1999
• "Asking the Right Questions of your Consulting Engineer"September 15, 1999
• "Gravity Tank-Draining Applications"October 15, 1999
• "Designing Systems for Startup and Shutdown"November 15, 1999
• "Changing Processes from Batch to Continuous"January 15, 2000
• "Solvent Extraction Options" February 15, 2000
• "Temperature Rise in Recirculated Systems" March 15, 2000
• "Using Flow Region to Ensure Correct Pipe Size" April 15, 2000
• "Use the Web Instead of Spreadsheets for "What-if" Scenarios" June 15, 2000
• "Building Efficient Facilities" July, 2000
• "Solvent Removal in Biotech" September 15, 2000
• "Moving Manufacturing into Bioprocess Arena" November 1, 2000
• "Mixing Methodology for Biotech" January 15, 2001
• "Permanent Magnetic Couplings for Bioprocess" March 15, 2001
• "Capacity for Batch and Continuous Equipment" April 15, 2001
• "Making Choices in Process Development" May 15, 2001
• "Cost/Benifit Analysis for Process Engineers" August, 2001
• "Rules of Thumb for Pumps & Piping Systems" November 15, 2001
• "Incorporating Continuous Equipment Early On" December, 2001
• "New Continuous Chromotography Options" Feb. 15, 2002
• "Continuous Precipitation & Crystalization Systems" March 15, 2002
• "Process and Equipment for Controlling Stability" May 15, 2003

Chemical Online / Pharmaceutical Online Column

I have also written a number of columns on technology issues in Chemical Online and/or Pharmaceutical Online. A list of the past columns on this subject are:

• "Finding Incentives for Equipment Innovation in Biotechnology" 7/21/99
• "On-Line Pump System Design Program" 7/7/99
• "Compressible Flow Refresher" 9/17/99
• "Taking E-commerce to the Next Level for the Pharmaceutical Industry"12/23/99
• "Online HVAC Duct Calculations"2/28/2000

Draining Time for Unpumped Tanks

Calculating gravity-powered flows can be tricky because the head changes with time and vessel shape. Chemical Engineering June 2000, pp. 115-119.

Manufacturing - The Next Frontier for Biotechnology

By tapping into the knowledge avaliable in the chemical process industries, biotech companies can profit from the high potential of their industry. View point BioPharm September 1993.

Optimize Cycle Times for Batch Biokill Systems

Outlines the design and optimization of batch bioinactivation systems normally present in facilities using fermentors and/or bioreactors to produce their products. Chemical Engineering Progress October 1994.

Think Small

One way to minimize new plants' required size is to convert more aspects of pharmaceutical processes from batch to continuous systems, Pharmaceutical Manufacturing, Fall 2002.

Steadfast's Disposable Rotary-Drum Filter

Continuous Cake Filtration Device for Smaller Batches of Material, Genetic Engineering News, September 15, 2002.

Small Scale Continuous Cake Filtration using the Disposable Rotary Drum Filter

Steadfast Equipment explains how the introduction of the disposable rotary drum filter will enable users to take advantage of the process improvements associated with continuous cake filtration equipment, Filtration+Separation, 5 Nov 2003.

Blinded by Science?

Input from other industries can assist in making efficent Biopharmacuetical processes, Editorial, Bioprocess International, January 2004.

Plasmid DNA Purification Possibilities using the Disposable Rotary Drum Filter

This article will explore the use of these separation capabilities, combined with a new device, the Disposable Rotary Drum Filter, to produce a method analogous to continuous affinity chromatography that has the ability to economically purify plasmid DNA with ease and scalability, Bioprocess International, February 2004.

Conference/Meeting Papers